Understand. Build. Discover.

Open tools for
scientific discovery.

Connecting scientific questions, software and experiments.

Research software

Built for the work
behind the discovery.

Open-source tools for
imaging-based spatial biology.

01 Image analysis

U-FISH

Find the signal.
Keep the detail.

Bring diverse FISH images into a unified signal representation, then locate fluorescent spots. A compact neural network makes detection practical across different image backgrounds, in both 2D and 3D.

  • 2D & 3D detection
  • Python & CLI
  • napari plugin
Genome Biology · 2025
Concept illustration: diverse FISH images pass through UFish-Net to a unified signal representation and localized spots.
Concept illustration

02 Probe design

U-Probe

Your experiment.
Your probe architecture.

Describe probe components and constraints in YAML, then assemble and filter candidates in a reproducible workflow. Use established FISH designs or create custom structures, with optional AI-agent assistance.

  • Custom architectures
  • Automated quality checks
  • Agent-ready
bioRxiv · Preprint
Concept illustration: YAML-defined parts, structure and constraints feed assembly and quality checks, yielding different FISH probe architectures.
Concept illustration